Involvement of nigrostriatal dopaminergic system in the gnawing behaviors induced by clonidine plus muscimol in mice
山口医学 Volume 40 Issue 5
Page 541-549
published_at 1991-10
Title
ClonidineとMuscimolの併用投与によるGnawing(かじり)反応への中枢Dopamine神経系の関与について
Involvement of nigrostriatal dopaminergic system in the gnawing behaviors induced by clonidine plus muscimol in mice
Creators
Kaneyuki Hiroshi
Creators
Ushijima Itsuko
Creators
Ukita Takeshi
Creators
Misuki Yasushi
Creators
Yamada Michio
Source Identifiers
The neurochemical and behavioral studies were carried out to clarify the neuronal mechanisms involved in the stereotype gnawing behaviors induced by clonidine (as an adenosine antagonist) plus muscimol (a GABA-a agonist) in mice. Combined treatment of clonidine (20mg/kg ip) and muscimol (0.5mg/kg ip) significantly increased 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in the dosal striatum as compared with saline group. Conversely, DOPAC levels in the medial prefrontal cortex tended to decrease, but not significantly. There was no significant change in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels among any regions. The frequency of gnawing behaviors was proportional to the dose of muscimol (0.25-1.0mg/kg), but not to that of clonidine (20-40mg/kg). Gnawing behaviors were hardly produced by muscimol (0.5mg/ kg) or clonidine (20mg/kg) alone. Haloperidol (0.1, 0.2mg/kg ip), but neither bisusulline (1.0-3.0mg/kg ip
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1991-10
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部