A Patient with Corticosteroid-resistant Active Ulcerative Colitis who Responded Well to Centrifugal Leukocyte Apheresis
山口医学 Volume 48 Issue 5
Page 219-225
published_at 1999-10
Title
白血球除去療法が有効であった難治性潰瘍性大腸炎の1症例
A Patient with Corticosteroid-resistant Active Ulcerative Colitis who Responded Well to Centrifugal Leukocyte Apheresis
Creators
Saiki Yasuhiko
Creators
Saito Yuki
Creators
Akazawa Tetsuko
Creators
Kurokawa Humie
Creators
Yanai Hideo
Creators
吉田 秀雄
Creators
Yosida Tomoharu
Creators
Okita Kiwamu
Source Identifiers
Creator Keywords
潰瘍性大腸炎
白血球除去療法
This report presents a patient with corticosteroid-resistant active ulcerative colitis who was successfully treated by centrifugal leukocyte apheresis. A 15-year-old female who had suffered from left-sided ulcerative colitis for 16 months, was successfully treated with steroid therapy (predonine, 5 mg/day, for 12 months) . In April, 1998, fourteen months after remission of the first episode, the colitis recurred. This time, however, the patient did not respond to steroid therapy (predonine, 30 mg/day, for 4 days, followed by high-dose methylprednisolone). Therefore, she received treatment with centrifugal leukocyte apheresis in addition to steroid therapy (predonine, 60 mg/day). Apheresis (removal of 0.94 x10^10 leukocytes / treatment) was conducted once a week. After 5 weeks, the colitis remitted and the steroid dose was reduced. In spite of effectiveness of steroid therapy in therapy of ulcerative colitis, its adverse effects have been recognized well. Centrifugal leukocyte apheresis may be an effective alternative treatment for patients who do not respond to steroid therapy. Apheresis also reduced the adverse effects of steroid therapy.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1999-10
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部