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Interferon-α promotes heat-induced apoptosis in human myeloid leukemia cells

The bulletin of the Yamaguchi Medical School Volume 49 Issue 1-2 Page 15-21
published_at 2002-06
A020049000103.pdf
[fulltext] 257 KB
Title
Interferon-α promotes heat-induced apoptosis in human myeloid leukemia cells
Creators Seguchi Masato
Source Identifiers
Creator Keywords
interferon-α heat apoptosis
The effects of interferon-α (IFN α) treatment on following heat-induced apoptosis were evaluated in human myeloid leukemia cell line, U937. Incubation of U937 with 1000 U/ml of IFN α promoted heat-induced apoptosis in a dose- and time-dependent manner. Another human leukemia cell line, HL60, was also sensitized to heat-induced apoptosis by pretreatment with IFNα. To investigate the mechanism of sensitization, effects of IFNα on the expression of HSP70 and BCL-2, two major anti-apoptotic proteins, were evaluated. Both protains were upregulated by heat treatment, but irrespective of the presence or absence of IFNα. These results suggests that IFNα promotes heat-induced apoptosis in human myeloid leukemia cells through the mechanism whereby HSP70 or BCL-2 is not involved.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 2002-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部