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Serum Hepatitis B Antigen Particles in various Liver Diseases : Relation to Immunological Tests for Hepatitis B Antigen

The bulletin of the Yamaguchi Medical School Volume 22 Issue 2 Page 265-273
published_at 1975-06
A020022000208.pdf
[fulltext] 1.14 MB
Title
Serum Hepatitis B Antigen Particles in various Liver Diseases : Relation to Immunological Tests for Hepatitis B Antigen
Creators Harada Toshinori
Creators Takenami Toshihiko
Creators Kodama Takahiro
Creators Fujita Teruo
Source Identifiers
Immunological detection of HBAg and the electron-microscopic observation of HBAg particles were performed on 196 serum samples collected from a total of 183 cases consisting of 58 of acute hepatitis, 8 of prolonged hepatitis, 60 of chronic hepatitis, 30 of liver cirrhosis, 21 of hepatoma and 6 of fulminant hepatitis, and the results obtained by both techniques were studied comparatively. As the result, the discrepancy between both techniques was noted in 19.9% (35/196) of the total serum samples, and almost all of the discrepancy was seen in the serum samples which were negative for HBAg by radioimmunoassay but exhibitid the particles electron-microscopically. The incidence of HBAg in various liver diseases determined electron-microscopically was recorded at 63.7% (37/58) for acute hepatitis, at 60% (36/60) for chronic hepatitis including 66.6% (26/39) for aggresive form, at 50% (15/30) for liver cirrhosis and at 71.4% (15/21) for hepatoma, and these values were more than 10% higher than those determined by immunological techniques. These results indicated that electron microscopy was a more sensitive method than immunological tests for detecting HBAg and supported the hypothesis that HBAg may play some role in the development of chronic liver disease and hepatoma.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1975-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部