Biphasic Effect of 1, 1-dimethyl-4-phenylpiperazinium Iodide (DMPP) on the Guinea-pig Distal Colon
The bulletin of the Yamaguchi Medical School Volume 19 Issue 3-4
Page 109-115
published_at 1972-12
Title
Biphasic Effect of 1, 1-dimethyl-4-phenylpiperazinium Iodide (DMPP) on the Guinea-pig Distal Colon
Creators
Ohkawa Hiromichi
Creators
Kondo Hitoshi
Creators
Matsumoto Tadami
Source Identifiers
1. Effect of DMPP on the contractile activity of guinea-pig distal colon were investigated in normal solution and in various autonomic blocking drugs. 2. Biphasic response was produced by DMPP and the effect of DMPP was blocked by tetradotoxin. The initial contraction in response to DMPP was diminished in physostigmine. 3. The effect of DMPP in guanethidine was nearly similar to that in contral. 4. It is concluded that DMPP stimurated the cholinergic excitatpry neurones in enteric plexus and produced the initial contraction. The relaxation by DMPP may due to stimulating action of DMPP on non-adrenergic inhibitory neurones.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1972-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部