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Neuronal basis of behavioral responses to reward-predictive cues

The bulletin of the Yamaguchi Medical School Volume 56 Issue 3-4 Page 33-36
published_at 2009
A050056000302.pdf
[fulltext] 576 KB
Title
Neuronal basis of behavioral responses to reward-predictive cues
Creators Ishikawa Akinori
Source Identifiers
Creator Keywords
anterior cingulate cortex basolateral amygdala discriminative stimulus nucleus accumbens prelimbic cortex
Cue-evoked reward-seeking behaviors require recognition of learned cues that predict reward availability and selection of appropriate motor responses to the cues. Multiple brain areas such as the nucleus accumbens (NAc), dorsomedial prefrontal cortex (dmPFC), basolateral amygdala and ventral tegmental area contribute to the performance of cue-evoked reward-seeking behavior. However, less is known about function of the neuronal circuits consisting of those brain regions. Recent study has reported the importance of projections from the dmPFC to the NAc core in behavioral and NAc neuronal responses to reward-predictive cues in a discriminative stimulus (DS) task in which and intermittently presented cue directs rats to make and operant response for reward. Here I review the neuronal mechanism underlying cue-evoked reward-seeking behaviors focusing on behavioral, anatomical and electrophysiological evidence for the significance of dmPFC projections to the NAc core in cue responding in the DS task.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2009
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 大学院医学系研究科(医学)