The development of a variable threshold analysis method to identify clones linked the clinicopathological features in an array-based CGH : its application to colorectal cancer

The development of a variable threshold analysis method to identify clones linked the clinicopathological features in an array-based CGH : its application to colorectal cancer

Creators Nakao Motonao

Creators Uchiyama Tetuji

Creators Adachi Jun

Creators Furuya Tomoko

Creators Oga Atsunori

Creators Kawauchi Shigeto

Creators Sasaki Kohsuke

In an array-based CGH, the analytical results of an evaluation of an abnormal number of copies are substantially affected by the designation of a cut off value for the ratio of the fluorescence intensity. In this study, we developed an array-based CGH analysis method that enables the designation of an optimal cut off value adapted to the analysis. With this method, the threshold of each BAC clone fluctuates automatically depending on the number of samples in order to enable the identification of a BAC clone correlated with the clinicopathological parameters…

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