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Adenylate kinase : An Old Enzyme with New Aspects

The bulletin of the Yamaguchi Medical School Volume 47 Issue 3-4 Page 37-45
published_at 2000-12
A020047000301.pdf
[fulltext] 4.42 MB
Title
Adenylate kinase : An Old Enzyme with New Aspects
Creators Nakazawa Atsushi
Source Identifiers
Creator Keywords
High-energy phosphate isozyme hemolytic anemia neuronal process evolution
Adenylate kinase (AK) catalyzes a reversible high-energy phosphoryl transfer reaction between adenine nucleotides. The enzyme contributes to the homeostasis of cellular adenine nucletide composition in addition to the nucleotide biosynthesis. We characterized cDNA and determained the gene structures of three AK isozymes, AK1, AK2 and AK3. The genetic basis of a case of AK1 deficiency was clarified as a single-base substitution in one the patient's chromosomes leading to the Arg to Trp change in the protein. We found that AK1 is localized in neuronal prosesses at high concentrations, which is probably related to a new regulatory function of AK as the high-erergy β-phosphoryl transfer chain from the ASP-synthesizing sites to the ATP-utilizing sites in the cell. AK2 and AK3 are mitochondrial proteins
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 2000-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部