Different Localization of Vitamin D Dissolved in Oil and in Water in the Rat Liver Revealed by Fluorescence Microscopy

水性ビタミンD_3と油性ビタミンD_2の筋注によるラット肝臓内の分布のちがい

Different Localization of Vitamin D Dissolved in Oil and in Water in the Rat Liver Revealed by Fluorescence Microscopy

Creators Makita Takashi

Creators Kozono Tatuziro

Creators Morimoto Masatoshi

Creators Kiwaki Sukechika

With intramuscular injections of aqueous vitamin D_s, fluorescent spots were predominantly localized in the fat-storing cells of the hepatic sinusoid. None of the hepatocyte had any indication of intracellular storing of vitamin D even with 10 injections of 10,000 I. U. per 100g of body weight. On the other hand the injections of vitamin D_2 dissolved in oil appeared to be stored in the rat heparocytes. This difference in localization was evident after 3 injections or more of vitamin D. With over-dose injection of vitamin D the rats in the group of aqueous solution experiments looked quite similar to those in control group. While the rat in the group that was injected with vitamin D_2 dissolved in oil vecame lifeless. ....

[ISSN]0513-1715

[NCID]AN00244250