The Measurement of Brainstem Blood Flow in the Experimental Recirculation Model of Brainstem Ischemia in the Rat
The bulletin of the Yamaguchi Medical School Volume 37 Issue 1-2
Page 25-30
published_at 1990-06
Title
The Measurement of Brainstem Blood Flow in the Experimental Recirculation Model of Brainstem Ischemia in the Rat
Creators
Shiroyama Yujiro
Creators
Nagamitsu Tsutomu
Creators
Abiko Seisho
Creators
Ito Haruhide
Source Identifiers
Creator Keywords
Brainstem
Ischemia
Recirculation
Hyperperfusion
Vasomotor center
This report describes a surgical approach and measurement of brainstem blood flow (BBF) used in experimental ischemic model of the brainstem. The vertebral artery of Wistar rat was exposed and prepared embolic thread was inserted into the vertebral artery. The lesions of the baselar artery occuleded animals were restricted to the brainstem which, in the rat, is normally supplied by the vertebrobasilar artery. Using the hydrogen clearance techniques, blood flow of the brainstem was measured in 21 rats. The mean value of mean blood pressure (MBP) was 96.2±6.2 mmHg before ischemia. It dropped to 62.0±12.4 mmHg after transient hypertension. The preischemic BBF was 35.5±2.4 ml/100g/min. This was followed by a gradual increase to hyperperfusion after recirculation. After 1 hour of recirculation, BBF rose to a level above 78.9±5.9 ml/100g/min. These findings suggest that this model may be useful in the evaluation of pathophysiogical changes in brainstem ischemia.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1990-06
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部