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The Measurement of Brainstem Blood Flow in the Experimental Recirculation Model of Brainstem Ischemia in the Rat

The bulletin of the Yamaguchi Medical School Volume 37 Issue 1-2 Page 25-30
published_at 1990-06
A020037000104.pdf
[fulltext] 1.99 MB
Title
The Measurement of Brainstem Blood Flow in the Experimental Recirculation Model of Brainstem Ischemia in the Rat
Creators Shiroyama Yujiro
Creators Nagamitsu Tsutomu
Creators Yamashita Tetsuo
Creators Abiko Seisho
Creators Ito Haruhide
Source Identifiers
Creator Keywords
Brainstem Ischemia Recirculation Hyperperfusion Vasomotor center
This report describes a surgical approach and measurement of brainstem blood flow (BBF) used in experimental ischemic model of the brainstem. The vertebral artery of Wistar rat was exposed and prepared embolic thread was inserted into the vertebral artery. The lesions of the baselar artery occuleded animals were restricted to the brainstem which, in the rat, is normally supplied by the vertebrobasilar artery. Using the hydrogen clearance techniques, blood flow of the brainstem was measured in 21 rats. The mean value of mean blood pressure (MBP) was 96.2±6.2 mmHg before ischemia. It dropped to 62.0±12.4 mmHg after transient hypertension. The preischemic BBF was 35.5±2.4 ml/100g/min. This was followed by a gradual increase to hyperperfusion after recirculation. After 1 hour of recirculation, BBF rose to a level above 78.9±5.9 ml/100g/min. These findings suggest that this model may be useful in the evaluation of pathophysiogical changes in brainstem ischemia.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1990-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部