Effects of Diethyldithiocarbamate on Superoxide and Nitric Oxide Production by Neutrophils
山口医学 Volume 42 Issue 6
Page 379-386
published_at 1993-12
Title
Diethyldithiocarbamateが好中球のsuperoxide及び nitric oxide産生に与える影響
Effects of Diethyldithiocarbamate on Superoxide and Nitric Oxide Production by Neutrophils
Creators
Izumi Yukie
Source Identifiers
Creator Keywords
Diethydithiocarbamate
好中球
nitric oxide
活性酸素
We investigated the effect of DDC on nitric oxide (NO) production by neutrophils and activating mechanism of neutrophils. The results were as follows: (1) DDC at high concentration inhibited both nitric oxide (NO) and nitrite (NO_2) Production by rat neutrophils. This decrease may induce O_2^- accumulation. (2) DDC stimulated Or Production by neutrophils in a dose-dependent manner. (3) DDC inhibited myeloperoxidase (MPO) activity of neutrophils in a dose-dependent manner. (4) The O_2^- release by DDC decreased by pertussis toxin, protein kinase C inhibitor, myosin light chain kinase inhibitor, calmodulin antagonist, EGTA and diltiazem. From these results, it is suggested that DDC may induce gastric mucosal damage by stimulating O_2^- release from neutrophils via receptor-mediated process and by inhibition of NO generation. Moreover, protein kinase C and calcium ion may play important roles in this stimulating process.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1993-12
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部