Spontaneous Amyloidosis in Senile ICR Mice Maintained Semi-barrier System

セミバリアシステムで飼育した高齢ICRマウスの自然発症アミロイドーシスについて

Spontaneous Amyloidosis in Senile ICR Mice Maintained Semi-barrier System

Creators Ikegami Jiro

Incidence and characterization of amyloid deposits were refered in 64 mice, aged 83 weeks old of each sex (26 male and 38 female) of inbred Sic: ICR. The mice were raised under semi-barrier conditions, room temperature at 22～26℃, ventilation at 20 times/hour and relative humidity at 45～65% with 12 hour light-dark cycle. They were fed a commercial diet (FR-2 10 kGy, Funabashi Farms, Chiba) and filtrated tap water ad libitum. Histologically amyloidosis were observed in 35 out of 64 mice(54.7%), 16 out of 26 male mice(61.5%) and 19 out of 38 female mice(50%). The amyloid deposits were detected in 32 out of64 mice(50%) in the kidney, 30 out of 64(46.9%) in the small intestine, 26 out of 64(40.6%) in the liver, 25 out of 64(39.1%) in the adrenal gland, 24 out of 62(38.7%) in the mesenteric lymph node, 20 out of64(31.2%)in the lung and 14 out of64(21.9%) in the spleen. Immunohistochemically 34 mice had AApoA II g amyloid protein. Only one mouse had AA amyloid protein.

[ISSN]0513-1731

[NCID]AN00243156