Forensic pharmacokinetics of alcohol

Forensic pathologists often offer interpretations of blood alcohol concentrations(BAC) found at autopsy. It is important to have a comprehensive knowledge of the pharmacokinetics of alcohol. A one-compartment model with zero-order elimination kinetics, which was proposed by Widmark, has been used to predict the BAC of an individual. However, non-linear kinetic nature of alcohol disposition is well-known. The elimination of alcohol form the body can be described by a Michaelis-Menten elimination kinetic model or a parallel first-order and Michaelis-Menten elimination kinetic model. The relationship among these models is studied. The bioavailability of alcohol was calculated using these models. Our results pointed out the overestimation by the calculation method using area under the curve(AUC). Population pharmacokinetic was introduced into ethanol kinetics. Bayesian methods were useful to estimate the blood ethanol concentration.

アルコール

法医薬物動態学

ミカエリス・メンテン型消失モデル

初回通過効果

ポピュレーション・ファーマコキネティクス

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである