Onset of Shwannoma Thirteen Years after Allogeneic Bone Marrow Transplantation in a Malignant Lymphoma Patient

A patient of 30 year-old male received allogeneic bone marrow transplantation (BMT) for malignant lymphoma at his age of 18 in 1985. The preconditioning regiｍen for BMT was by cyclophosphamide and total body irradiation. Acute graft versus host disease (GVHD) and chronic GVHD were mild except for the cicatrical pemphigoid which caused the stenosis of the vocal cord 3 years after BMT. He complained of back pain since 1997. The pain and paralysis of the legs progressed in July 1998. The findings of computed tomography and magnetic resonance imaging revealed the sand-glass like tumor at Th 10-1 1. Urgent operation was performed, tumor was totally resected, and the pathological findings of the resected materials revealed schwannoma (Antoni B type). The pain and paralysis of the legs disappeared immediately after the operation. The causal relationship between schwannoma: and allogeneic BMT was discussed.

骨髄移植

移植後腫瘍

神経鞘腫