Fatty Acids Compositions in Epidermal Cyst　and Psoriatic

Fatty acid obtained from epidermal cyst and psoriatic scale were studied in order to elucidate error of lipid metabolisms concerning keratinization. Lipids from contents of an epidermal cyst and scale obtained from a patient with psoriasis vulgaris, were analyzed quantitatively and compared with those of epidermal cyst, clavushorny layer from normal volunteers. The thin-layer chromatography was used for detection of cholesterol ester, triglyceride, free fatty acids, cholesterol and phospholipids. Fatty acid components of some lipids were converted to methyl esters and confirmed by gas-liquid chromatography (GLC). The fatty acid compositions of scale and an epidermal cyst of psoriatic patient revealed smaller amount of C18:0 and greater amount of C18:1 and C18:2 than those of clavus horny layer and an epidermal cyst of normal volunteers. The increase ofC18:2in psoriatic scale suggests that much linoleic acid might be transported into corneocytes from serum. The increase of C18:1 and C18:2 may contribute to membrane fluidity, leading to suppression of terminal differentiation.

低リノール酸血症

乾癬鱗屑

粉瘤

組織中脂肪酸