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Native English scholarly writers use interactional metadiscourse markers in their research articles to indicate their stance and negotiate their claims with readers. Hedges are a type of interactional metadiscourse marker often used in scientific research articles to soften writers’ claims and protect themselves from criticism (Hyland, 2005a). When Japanese researchers write research articles in English, they tend to use fewer English hedges than native English writers. Although hedges are used in research articles written in Japanese, their usage appears to differ from that of English hedges. This study analyses the use of hedges in research articles by Japanese writers in both English and Japanese in comparison with English hedges employed by native English writers in order to reveal the differences in the use of hedges between the two languages. The analysis focuses not only on the discrepancies in usage between native English and Japanese writers, but also on the characteristics of hedges used in academic articles written in English and Japanese. Furthermore, this study investigates the impact of Japanese writers’ first language on their use of English hedges in articles written in English. A total of 30 published empirical research articles in soft science disciplines in English and Japanese were used for the quantitative and qualitative analyses of the use of hedges, revealing both the writing and linguistic differences between the two languages. Thus, this study aims to offer pedagogical suggestions for Japanese learners of English to use hedges more effectively in their research papers written in English.

The fluctuation hypothesis (Ionin et al., 2004) holds that learners of English as a second or foreign language (ESL/EFL) will continue to make errors in their use of English articles until they switch their criteria for English article selection from specificity to definiteness. However, L1 language acquisition research indicates that young children who are L1 speakers use English articles accurately on the basis of whether the referent is specific or nonspecific before they acquire the definite–indefinite distinction. It is possible that Japanese EFL learners, like young L1 learners, can accurately use English articles employing the specific–non-specific distinction even before they master the definite–indefinite distinction. This study examined this hypothesis using Bickerton’s (1981) semantic wheel-based taxonomy and Díez- Bedmar and Papp’s (2008) tag-coding system. An analysis of 38 essays from the Nagoya Interlanguage Corpus of English Reborn showed that the specific– non-specific distinction can contribute to a highly accurate use of English articles for non-specific referents and relatively accurate article use for specific referents by Japanese EFL learners who have difficulty applying the definite– indefinite distinction. The pedagogical implications of the results were discussed.

Right ventricular (RV) dysfunction and its linked arrhythmias play a crucial role in determining the prognosis of pulmonary arterial hypertension (PAH). Our paper aimed to explore the potential protective effects of direct pharmacological intervention in the RV muscle using dantrolene (DAN), a stabilizer of the cardiac ryanodine receptor (RyR2), against RV dysfunction and arrhythmia in a rat model of monocrotaline (MCT)-induced PAH. To induce PAH, male 8-week-old Sprague-Dawley rats received MCT injections. The study also assessed the induction of ventricular tachycardia (VT) by catecholamines, examining RyR2-mediated Ca^{2+} release properties in isolated cardiomyocytes. Additionally, a pulmonary artery-banding model was established to evaluate the independent effects of chronic pressure overload on RV morphology and function. In the MCT-induced PAH rat model, findings revealed RV hypertrophy, dilation, and functional decline, resulting in 0% survival rate two months post-MCT induction. Conversely, chronic DAN treatment demonstrated improvements in these RV parameters and an 80% increase in survival. Furthermore, chronic DAN treatment prevented the dissociation of calmodulin from RyR2, inhibiting Ca^{2+} sparks and spontaneous Ca^{2+} transients in MCT-induced hypertrophied RV cardiomyocytes. Epinephrine induced VT in over 50% of rats with MCT-induced PAH, while chronic DAN treatment achieved complete suppression of VT. The paper concludes that stabilizing RyR2 with DAN holds promise as a novel therapeutic approach against the development of RV dysfunction and fatal arrhythmias associated with PAH.

本稿では、まず人工知能の根幹に係る一般パターン認識の問題を明らかにするとともに、その解決に有用な統計的パターン認識とそれを発展させた離散Bayes識別則を概説する。次に離散Bayes識別則の個別化医療への応用としての診断・予測問題と創薬における治験問題に言及する。