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- Oda Tetsuro
Oda Tetsuro
Affiliate Master
Yamaguchi University
Publish Date (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Medical Science & Innovation Volume 70 Issue 1-2
pp. 7 - 17
published_at 2023-06
To investigate whether dantrolene (DAN), cardiac ryanodine receptor (RyR2) stabilizer, improves impaired diastolic function in an early pressure-overloaded hypertrophied heart, pressure-overload hypertrophy was induced by transverse aortic constriction (TAC) in mice. Wild-type (WT) mice were divided into four groups: sham-operated mice (Sham), sham-operated mice treated with DAN (DAN+Sham), TAC mice (TAC), and TAC mice treated with DAN (DAN+TAC). The mice were then followed up for 2 weeks. Left ventricular (LV) hypertrophy was induced in TAC, but not DAN+TAC mice, 2 weeks after TAC. There were no differences in LV fractional shortening among the four groups. Catheter tip micromanometer showed that the time constant of LV pressure decay, an index of diastolic function, was significantly prolonged in TAC but not in DAN+TAC mice. Diastolic function was significantly impaired in TAC, but not in DAN+TAC mice as determined by cell shortening and Ca^{2+} transients. An increase in diastolic Ca^{2+} leakage and a decrease in calmodulin (CaM) binding affinity to RyR2 were observed in TAC mice, while diastolic Ca^{2+} leakage improved in DAN+TAC mice. Thus, DAN prevented the progression of hypertrophy and improved the impairment of LV relaxation by inhibiting diastolic Ca^{2+} leakage through RyR2 and the dissociation of CaM from RyR2.
Creators :
Chang Yaowei
Kobayashi Shigeki
Yano Yasutake
Uchida Tomoyuki
Nawata Junya
Fujii Shohei
Nakamura Yoshihide
Suetomi Takeshi
Uchinoumi Hitoshi
Oda Tetsuro
Yamamoto Takeshi
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 65 Issue 3-4
pp. 27 - 35
published_at 2018
Creators :
Nishimura Takashi
Okamura Takayuki
Tateishi Hiroki
Fujimura Tatsuhiro
Oda Tetsuro
Wada Yasuaki
Okuda Shinichi
Omuro Ayumi
Maeda Takako
Hamada Yoriomi
Nanno Takuma
Fukui Go
Yamada Jutaro
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 63 Issue 1-2
pp. 5 - 16
published_at 2016
We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients
Creators :
Oda Seiko
Kobayashi Shigeki
Nanno Takuma
Ishiguchi Hironori
Myoren Takeki
Murakami Wakako
Mochizuki Mamoru
Oda Tetsuro
Okuda Shinichi
Yamada Jutaro
Okamura Takayuki
Matsuzaki Masanori
Yano Masafumi
Publishers : Yamaguchi University School of Medicine