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Analysis of single nucleotide polymorphisms of the aryl hydrocarbon receptor in japanese psoriasis patients

The bulletin of the Yamaguchi Medical School Volume 63 Issue 3-4 Page 41-48
published_at 2016
A050063000302.pdf
[fulltext] 530 KB
Title
Analysis of single nucleotide polymorphisms of the aryl hydrocarbon receptor in japanese psoriasis patients
Creators Nakamura Akiko
Creators Nakamura Yoshitaka
Creators Tanaka Akemi
Creators Muto Masahiko
Source Identifiers
Creator Keywords
aryl hydrocarbon receptor psoriasis vulgaris single nucleotide polymorphism disease susceptibility to psoriasis
The aryl hydrocarbon receptor (AHR) is a dioxin receptor that activates the differentiation of T helper 17 (Th17) cells and regulatory T (Treg) cells to produce interleukin-22 (IL-22). In whole exome sequence analysis, we found two single nucleotide polymorphisms (SNPs) in AHR, rs2074113 and rs2066853. In addition, we investigated the correlation between these AHR SNPs and susceptibility to psoriasis in 185 patients with psoriasis vulgaris (PV) and 145 healthy controls by using TaqMan® SNP Genotyping assays. For rs2074113, in both groups the frequency of the G allele was 0.59 and that of the T allele was 0.41. For rs2066853, in both groups the frequency of the A allele was 0.42 and that of the G allele was 0.58. Thus both allele frequencies in both groups were not significantly different and therefore the frequency of AHR SNPs and susceptibility to PV were not correlated. However, in a comparison of HLA-C^* 06:02-positive and -negative patients, rs2066853 AA homozygotes were significantly decreased in HLA-C^* 06:02-positive PV patients compared to HLA- C^* 06:02-negative PV patients after Bonferroni correction. These observations suggested that AHR rs2066853 may be a protective gene for psoriasis in the Japanese population.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2016
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部附属病院 大学院医学系研究科(医学)