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医学部
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山口医学 Volume 52 Issue 1-2
pp. 5 - 6
published_at 2003-04-30
山口医学 Volume 52 Issue 1-2
pp. 7 - 11
published_at 2003-04-30
山口医学 Volume 52 Issue 6
pp. 285 - 295
published_at 2003-12-31
Creators :
Kuriyama Ryutaro
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6
pp. 297 - 302
published_at 2003-12-31
Creators :
Nakazora Tatsuki
Yanai Hideo
Nakamura Youhei
Kitou Tomoko
Okita Kiwamu
Matsumoto Yusuke
Oka Masaaki
Sasaki Kousuke
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 5
pp. 175 - 182
published_at 2003-10-31
Creators :
Kunishi Yoshihiko
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 5
pp. 183 - 187
published_at 2003-10-31
Creators :
Miyazaki Mutsuko
Taguchi Akihiko
Sakuragi Shizu
Shinohara Kenji
Inoue Yasushi
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 5
pp. 189 - 194
published_at 2003-10-31
Creators :
Numa Fumitaka
Sueoka Kohtaro
Nawata Shugo
Sumie Masahiro
Kawasaki Keiko
Umayahara Kenji
Ogata Hidenobu
Sugino Norihiro
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6
pp. 211 - 218
published_at 2003-12-31
山口医学 Volume 52 Issue 6
pp. 255 - 262
published_at 2003-12-31
Creators :
Morinobu Kenichi
Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6
pp. 263 - 273
published_at 2003-12-31
Creators :
Kaneko Noboru
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 6
pp. 279 - 289
published_at 2004-12-31
Creators :
Nakamura Ippei
Okuda Masayuki
Kage Haruko
Kunitsugu Ichiro
Sugiyama Shinichi
Fujii Akihiro
Matsubara Asako
Tan Nobusuke
Hobara Tatsuya
Publishers : 山口大学医学会
山口医学 Volume 54 Issue 1
pp. 5 - 11
published_at 2005-02-28
Creators :
Kanda Takashi
Publishers : 山口大学医学会
山口医学 Volume 54 Issue 6
pp. 163 - 164
published_at 2005-12-31
Creators :
Suzuki Michiyasu
Kunitsugu Ichiro
Kato Shoichi
Fujisawa Hiroaki
Kajiwara Koji
Fujii Masami
Nomura Sasahiro
Houbara Tatsuya
Publishers : 山口大学医学会
山口医学 Volume 55 Issue 2-3
pp. 55 - 60
published_at 2006-06-30
山口医学 Volume 55 Issue 2-3
pp. 61 - 65
published_at 2006-06-30
Creators :
Mitsuoka Kouji
Mano Takamitsu
Okafuji Masaki
Yoshimura Tatsuo
Horinaga Daiju
Fukuda Teruyo
Ueyama Yoshiya
Publishers : 山口大学医学会
山口医学 Volume 55 Issue 5
pp. 167 - 172
published_at 2006-10-31
Creators :
Matsumoto Kanako
Matsuda Masako
Miyata Fumi
Karahi Sayaka
Ichihara Kiyoshi
Hirano Hitoshi
Publishers : 山口大学医学会
山口医学 Volume 54 Issue 1
pp. 13 - 22
published_at 2005-02-28
Creators :
Kurokawa Tetsu
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1
pp. 5 - 7
published_at 2004-02-29
山口医学 Volume 53 Issue 1
pp. 9 - 19
published_at 2004-02-29
山口医学 Volume 53 Issue 1
pp. 21 - 27
published_at 2004-02-29
Creators :
Fujii Kenzo
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1
pp. 39 - 45
published_at 2004-02-29
Creators :
Moriwaki Toru
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1
pp. 47 - 54
published_at 2004-02-29
Creators :
Terasaki Yutaka
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1
pp. 55 - 65
published_at 2004-02-29
Creators :
Murata Yoichiro
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 2
pp. 109 - 114
published_at 2004-04-30
Creators :
Kawano Kazuaki
Katoh Tomoe
Yagi Takaharu
Hirata Ken
Hayashi Masataro
Seyama Atsushi
Oga Atsunori
Publishers : 山口大学医学会
山口医学 Volume 53 Issue 3
pp. 127 - 131
published_at 2004-06-30
山口医学 Volume 53 Issue 3
pp. 133 - 137
published_at 2004-06-30
Creators :
Mori Naohide
Sakamoto Kazuhiko
Tamesa Takao
Okada Toshimasa
Takemoto Norikazu
Hashimoto Kiichirou
Tangoku Akira
Oka Masaaki
Publishers : 山口大学医学会
山口医学 Volume 56 Issue 2
pp. 31 - 36
published_at 2007-04-30
Creators :
Tsuruta Ryosuke
Kasaoka Shunji
Oda Yasutaka
Kaneda Kotaro
金子 唯
Fujita Motoki
Miyauchi Takashi
井上 健
Maekawa Tsuyoshi
Miyauchi Takashi
Publishers : 山口大学医学会
山口医学 Volume 56 Issue 2
pp. 37 - 41
published_at 2007-04-30
Creators :
Harada Eijiro
Shiraishi Kei
Enoki Tadahiko
Noshima Shinji
Hamano Kimikazu
Publishers : 山口大学医学会
The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4
pp. 25 - 31
published_at 2005-12
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators :
Okita Kiwamu
Sakaida Isao
Terai Shuji
Yamamoto Naoki
Omori Kaoru
Ishikawa Tsuyoshi
Aoyama Kouji
Shinoda Koh
Hamamoto Yoshihiko
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4
pp. 37 - 41
published_at 2005-12
Hepatocellular carcinoma (HCC) has a poor prognosis even after curative surgery, due to the high frequency of early intrahepatic recurrence (IHR). Conventional staging systems are almost completely inadequate, and need to be complemented by novel tools. To this end, many investigators have performed DNA microarray analysis on the basis of genome-wide information. However, so far, few studies have been able to truly account for the clinical efficacy of DNA microarray analysis in HCC. To address this dilemma, we used a supervised learning method with information of 7070 genes from 33 HCC samples, to construct a 12-gene predictor for early IHR, and then evaluated its predictive performance in 27 independent HCC samples. Our 12-gene predictor correctly predicted early IHR or non-recurrence in 25 (93%) of the 27 independent samples. This predictive value is higher than that of any other system currently available, suggesting that our system can serve as a robust tool for accurate prediction of early IHR of HCC. I emphasize in this mini-review that, although there are some technical issues to resolve prior to clinical use, DNA microarray technology can provide molecular basis to initiate “bench to bedside” translation, which cannot be easily reached with other methods.
The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4
pp. 43 - 53
published_at 2005-12
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators :
Yokoyama Emi
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4
pp. 55 - 60
published_at 2005-12
The purpose of this study was to compare demographic trends in the aging of the Japanese and Brazilian populations on the basis of health indicator data collected by the statistics bureaus of the Japanese and Brazilian governments. The demographic and health indicator data from surveys by the Statistics Bureaus of the Japanese and Brazilian governments and other sources were obtained from websites. The data showed that Japan has an aging population, that the number of elderly persons in Japan is increasing and that the Government of Japan has a plan to address future demands for health resources by this aging population, whereas Brazil has a rapidly population aging but no plan for its future health services. Brazil may need to increase the number of hospitals and hospital beds and develop a medical care plan for the elderly within its Unified Health System.
Creators :
Sendo Eliane Satie
Inoue Masaiwa
Laskar MS
Harada Noriaki
Publishers : Yamaguchi University School of Medicine