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Molecular Genetics and Metabolism Reports Volume 1 Issue 1 pp. 249 - 253
published_at 2014
Creators : Suzuki Akira Nagasaka Hironori Ochi Yasuhiro Kobayashi Kazuhiro Nakamura Hiroshi Nakatani Daisaku Yamaguchi Satoshi Yamaki Shinobu Wada Atsushi Shirata Yoshihisa Hui Shu-Ping Toda Tatsushi Kuroda Hiroshi Chiba Hitoshi Hirano Kenichi Publishers : Elsevier
山口医学 Volume 63 Issue 3 pp. 201 - 205
published_at 2014-08-01
Creators : Fukuda Yoshiharu Publishers : 山口大学医学会
山口医学 Volume 63 Issue 3 pp. 235 - 236
published_at 2014-08-01
Publishers : 山口大学医学会
山口医学 Volume 63 Issue 4 pp. 301 - 303
published_at 2014-11-01
Publishers : 山口大学医学会
Anticancer Res Volume 34 Issue 9 pp. 4807 - 4811
published_at 2014-11-01
Creators : Nawata Junya Kuramitsu Yasuhiro Wang Yufeng Kitagawa Takao Tokuda Kazuhiro Baron Byron Akada Junko Suenaga Shigeyuki Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : International Institute of Anticancer Research
山口医学 Volume 64 Issue 1 pp. 25 - 34
published_at 2015-02-01
Creators : Fukuda Yoshiharu Nakamura Hiroshi Segawa Makoto Harada Tadanari Taguchi Akihiko Abe Masaaki Publishers : 山口大学医学会
山口医学 Volume 64 Issue 3 pp. 191 - 197
published_at 2015-08-01
We held medical seminars for high-school students who hope to become physicians to increase their motivation and to encourage them to enter Yamaguchi University. The seminars were held two or three times a year at hospitals in six locations in Yamaguchi prefecture between 2011 and 2014, and consisted of observation of facilities in hospitals, physician lectures, experience of medical practice, and Q&A sessions with physicians and medical students. A total of 210 high-school students participated in 11 seminars. The questionnaires for the participants showed 89.9% of the participants rated the seminars“very good”and 91.4% responded,“my motivation was strengthened”.Of the seminar participants, 20 of 69 high-school graduates entered the Yamaguchi University School of Medicine. The follow-up survey showed that the percentage of medical school students studying at Yamaguchi University was 69.0% (20/29) for seminar participants and 45.5% (46/101) for non-seminar participants. The results suggest that the medical seminars were as effective as expected in encouraging high-school students to become physicians and to enter Yamaguchi University.
Creators : Fukuda Yoshiharu Nakamura Hiroshi Segawa Makoto Abe Masaaki Taguchi Akihiko Miyazaki Mutsuko Publishers : 山口大学医学会
山口医学 Volume 64 Issue 3 pp. 243 - 245
published_at 2015-08-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 4 pp. 291 - 295
published_at 2015-11-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 4 pp. 297 - 299
published_at 2015-11-01
Publishers : 山口大学医学会
山口医学 Volume 65 Issue 3 pp. 149 - 151
published_at 2016-08-01
Publishers : 山口大学医学会
山口医学 Volume 65 Issue 3 pp. 153 - 155
published_at 2016-08-01
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 1 pp. 69 - 70
published_at 2017-02-01
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 3 pp. 205 - 206
published_at 2017-08-01
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 4 pp. 243 - 245
published_at 2017-10-06
Publishers : 山口大学医学会
山口医学 Volume 67 Issue 3 pp. 175 - 177
published_at 2018-10-01
Publishers : 山口大学医学会
山口医学 Volume 67 Issue 3 pp. 179 - 181
published_at 2018-10-01
Publishers : 山口大学医学会
山口医学 Volume 68 Issue 1 pp. 5 - 12
published_at 2019-03-01
Creators : Hazama Shoichi Publishers : 山口大学医学会
山口医学 Volume 68 Issue 4 pp. 167 - 169
published_at 2019-12-11
Publishers : 山口大学医学会
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
Hepatocellular carcinoma (HCC) has a poor prognosis even after curative surgery, due to the high frequency of early intrahepatic recurrence (IHR). Conventional staging systems are almost completely inadequate, and need to be complemented by novel tools. To this end, many investigators have performed DNA microarray analysis on the basis of genome-wide information. However, so far, few studies have been able to truly account for the clinical efficacy of DNA microarray analysis in HCC. To address this dilemma, we used a supervised learning method with information of 7070 genes from 33 HCC samples, to construct a 12-gene predictor for early IHR, and then evaluated its predictive performance in 27 independent HCC samples. Our 12-gene predictor correctly predicted early IHR or non-recurrence in 25 (93%) of the 27 independent samples. This predictive value is higher than that of any other system currently available, suggesting that our system can serve as a robust tool for accurate prediction of early IHR of HCC. I emphasize in this mini-review that, although there are some technical issues to resolve prior to clinical use, DNA microarray technology can provide molecular basis to initiate “bench to bedside” translation, which cannot be easily reached with other methods.
Creators : Iizuka Norio Publishers : Yamaguchi University School of Medicine
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators : Yokoyama Emi Publishers : Yamaguchi University School of Medicine
The purpose of this study was to compare demographic trends in the aging of the Japanese and Brazilian populations on the basis of health indicator data collected by the statistics bureaus of the Japanese and Brazilian governments. The demographic and health indicator data from surveys by the Statistics Bureaus of the Japanese and Brazilian governments and other sources were obtained from websites. The data showed that Japan has an aging population, that the number of elderly persons in Japan is increasing and that the Government of Japan has a plan to address future demands for health resources by this aging population, whereas Brazil has a rapidly population aging but no plan for its future health services. Brazil may need to increase the number of hospitals and hospital beds and develop a medical care plan for the elderly within its Unified Health System.
Creators : Sendo Eliane Satie Inoue Masaiwa Laskar MS Harada Noriaki Publishers : Yamaguchi University School of Medicine