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A Patient with Corticosteroid-resistant Active Ulcerative Colitis who Responded Well to Centrifugal Leukocyte Apheresis

山口医学 Volume 48 Issue 5 Page 219-225
published_at 1999-10
B030048000505.pdf
[fulltext] 3.91 MB
Title
白血球除去療法が有効であった難治性潰瘍性大腸炎の1症例
A Patient with Corticosteroid-resistant Active Ulcerative Colitis who Responded Well to Centrifugal Leukocyte Apheresis
Creators Saiki Yasuhiko
Creators Higaki Shingo
Creators Saito Yuki
Creators Akazawa Tetsuko
Creators Kurokawa Humie
Creators Yanai Hideo
Creators 吉田 秀雄
Creators Yosida Tomoharu
Creators Okita Kiwamu
Source Identifiers
Creator Keywords
潰瘍性大腸炎 白血球除去療法
This report presents a patient with corticosteroid-resistant active ulcerative colitis who was successfully treated by centrifugal leukocyte apheresis. A 15-year-old female who had suffered from left-sided ulcerative colitis for 16 months, was successfully treated with steroid therapy (predonine, 5 mg/day, for 12 months) . In April, 1998, fourteen months after remission of the first episode, the colitis recurred. This time, however, the patient did not respond to steroid therapy (predonine, 30 mg/day, for 4 days, followed by high-dose methylprednisolone). Therefore, she received treatment with centrifugal leukocyte apheresis in addition to steroid therapy (predonine, 60 mg/day). Apheresis (removal of 0.94 x10^10 leukocytes / treatment) was conducted once a week. After 5 weeks, the colitis remitted and the steroid dose was reduced. In spite of effectiveness of steroid therapy in therapy of ulcerative colitis, its adverse effects have been recognized well. Centrifugal leukocyte apheresis may be an effective alternative treatment for patients who do not respond to steroid therapy. Apheresis also reduced the adverse effects of steroid therapy.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1999-10
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部