Rapid proliferation of CD22 negative leukemic cells after inotuzumab ozogamicin therapy for relapsed acute lymphoblastic leukemia

Inotuzumab ozogamicinの投与後にCD22陰性白血病細胞が急増した再発急性リンパ性白血病

Rapid proliferation of CD22 negative leukemic cells after inotuzumab ozogamicin therapy for relapsed acute lymphoblastic leukemia

We report the case of a 48-year-old woman with relapsed B-lineage acute lymphoblastic leukemia(B-ALL)following cord blood transplantation, in which leukemic cell CD22 antigens became negative after a single administration of inotuzumab ozogamicin(InO).At relapse, a major part of leukemic cells expressed CD19 and CD22 antigens, however some leukemic cells were negative for CD22. As treatment with blinatumomab proved ineffective, InO therapy was subsequently initiated

Creators Sakai Kohei

Creators Tominaga Takayuki

Creators Nakano Kohei

Creators Matsumura Takuro

Creators Tanaka Shinsuke

Creators Takahashi Toru