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The purpose of this study was to compare demographic trends in the aging of the Japanese and Brazilian populations on the basis of health indicator data collected by the statistics bureaus of the Japanese and Brazilian governments. The demographic and health indicator data from surveys by the Statistics Bureaus of the Japanese and Brazilian governments and other sources were obtained from websites. The data showed that Japan has an aging population, that the number of elderly persons in Japan is increasing and that the Government of Japan has a plan to address future demands for health resources by this aging population, whereas Brazil has a rapidly population aging but no plan for its future health services. Brazil may need to increase the number of hospitals and hospital beds and develop a medical care plan for the elderly within its Unified Health System.
Creators : Sendo Eliane Satie Inoue Masaiwa Laskar MS Harada Noriaki Publishers : Yamaguchi University School of Medicine
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators : Yokoyama Emi Publishers : Yamaguchi University School of Medicine
Hepatocellular carcinoma (HCC) has a poor prognosis even after curative surgery, due to the high frequency of early intrahepatic recurrence (IHR). Conventional staging systems are almost completely inadequate, and need to be complemented by novel tools. To this end, many investigators have performed DNA microarray analysis on the basis of genome-wide information. However, so far, few studies have been able to truly account for the clinical efficacy of DNA microarray analysis in HCC. To address this dilemma, we used a supervised learning method with information of 7070 genes from 33 HCC samples, to construct a 12-gene predictor for early IHR, and then evaluated its predictive performance in 27 independent HCC samples. Our 12-gene predictor correctly predicted early IHR or non-recurrence in 25 (93%) of the 27 independent samples. This predictive value is higher than that of any other system currently available, suggesting that our system can serve as a robust tool for accurate prediction of early IHR of HCC. I emphasize in this mini-review that, although there are some technical issues to resolve prior to clinical use, DNA microarray technology can provide molecular basis to initiate “bench to bedside” translation, which cannot be easily reached with other methods.
Creators : Iizuka Norio Publishers : Yamaguchi University School of Medicine
Creators : Shinohara Kenji Publishers : Yamaguchi University School of Medicine
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
Background and Aim: Image definition and complete small bowel examination rate are possible factors contributing to missed lesions during capsule endoscopy.This study aimed to determine the effect of coadministration of polyethylene glycol (PEG) and dai-kenchu-to (DKT) on these factors using PEG and DKT as pretreatment before capsule endoscopy. Methods: Patients who underwent capsule endoscopy at our hospital between November 2007 and August 2012 were included in the study. Patients were divided into the following three groups: those receiving no pretreatment (control, n=133), those orally administered PEG (PEG, n=20), and those orally administered PEG and DKT (15g) (PEG + DKT, n=25). Image definition and complete small bowel examination rate were examined retrospectively between the three groups. Results: Image definition in the PEG + DKT group was significantly higher than that in the control group (p<0.05), but there was no significant differences between the PEG and control groups. The complete small bowel examination rate was significantly lower in the PEG group than in the control and PEG + DKT groups (p<0.05). Conclusions: Coadministration of PEG and DKT improved image definition and prevented a reduction of the complete small bowel examination rate due to PEG in capsule endoscopy.
Creators : Suzuki Keiko Hashimoto Shinichi Shirasawa Tomohiro Yokota Tadayuki Kaneyama Satoko Shibata Hiroaki Tanabe Ryo Sakaida Isao Publishers : Yamaguchi University School of Medicine
Journal of Statistical Mechanics: Theory and Experiment Volume 2016 pp. 023206 -
published_at 2016-02-25
We study the diffusion of Brownian particles in a Gaussian random velocity field with short memory. By extending the derivation of an effective Fokker–Planck equation for the Lanvegin equation with weakly colored noise to a random velocity-field problem, we find that the effect of thermal noise on particles is suppressed by the existence of memory. We also find that the renormalization effect for the relative diffusion of two particles is stronger than that for single-particle diffusion. The results are compared with those of molecular dynamics simulations.
Creators : Ueda Masahiko Publishers : IOP Publishing
本研究の目的は,文献をもとに「育児困難感」と「育児不安」の用語の整理を行い,今後の支援に繋げる視点を得ることである。検討の結果,「育児困難感」は,実際の母親を取り巻く要因の中で,母親が子どもと対峙することで「母親自身が困っている」状態を示すものと考えられた。また「育児不安」は「育児における漠然とした不安」であり,疲労感や抑うつ状態が生じる可能性や,具体的な対象や問題がない場合でも生じることが考えられた。また「育児困難感」は「相手(子ども)への感情」であり,「育児不安」は「母親自身の不安」であり,2つは質的に異なると考えられ,「育児困難感」と「育児不安」の高低をもとに,5つのタイプに分類を試みた。
Creators : Kasuga Yumi Publishers : 山口大学大学院教育学研究科附属臨床心理センター
本研究は質問紙調査により挫折体験の意味づけとフォーカシング的経験および外傷後成長(Post-Traumatic Growth,以下“PTG”と表記)との関連を検討するものである。パス解析の結果,(1)フォーカシング的経験のうち「体験過程の受容と行動」はPTGを促進すること,(2)挫折体験の意味づけのうち「同化」はフォーカシング的経験の「間が取れている」と「体験過程の確認時間・空間の確保」,「体験過程の受容と行動」を促進し「体験の感受」を抑制すること,また(3)挫折体験の意味づけのうち「調節」は「体験の感受」と「体験過程の受容と行動」を促進すること,(4)人は挫折体験を経験した際,「同化」と「調節」の両方を体験しがちであることが示された。以上より「同化と調節の振り子モデル」が提示され,調節のみならず同化も有機体の実現傾向のあらわれとして位置づけうること,また一見進んでいないようにみえるクライエントのプロセスを受容することが,結果としてプロセスを進めることにつながるうることが示唆された。
Creators : Oshie Takashi Publishers : 山口大学大学院教育学研究科附属臨床心理センター
本研究の目的は,教員の教育相談研修への参加意欲を高める要因について検討することである。筆者が行った教育相談の継続研修の参加者14名を対象に,研修に継続参加した理由について自由記述による質問紙調査を行った。検討の結果,研修参加の要因として「ニーズや実践とつながる研究内容」「自分を見つめる・他者と共有し受け止められる時間」は「ニーズや実践とつながる研究内容」や「研究方法・環境の工夫」の両方の側面を持つと考えた。
Creators : Kasuga Yumi Publishers : 山口大学大学院教育学研究科附属臨床心理センター
本研究は挫折体験により知覚されたストレスとフォーカシング的態度および自己成長感との関連を検討するものである。パス解析の結果,(1)挫折体験により知覚されたストレスは問題意識性を高め,フォーカシング的態度による吟味のプロセスを経て自己成長感を高めること,(2)挫折体験により知覚されたストレスはフォーカシング的態度を抑制することが示された。あわせて本研究の結果が臨床に示唆する意義について議論した。
Creators : Oshie Takashi Publishers : 山口大学大学院教育学研究科附属臨床心理センター
The hippocampal dentate gyrus has been identified to play a critical role in maintaining contextual memory in many mammalian species. To evaluate learninginduced synaptic plasticity of granule cells, we subjected male rats to an inhibitory avoidance (IA) task and prepared acute hippocampal slices. In the presence of 0.5 μM tetrodotoxin, we recorded miniature excitatory post synaptic currents (mEPSCs) and inhibitory post synaptic currents (mIPSCs) in male rats experiencing four groups: untrained, IA-trained, unpaired, and walk-through. Compared with the untrained, IA-trained, unpaired, and walk-through groups, the unpaired group significantly enhanced mean mEPSC amplitudes, suggesting the experience-induced plasticity at AMPA receptor-mediated excitatory synapses. For inhibitory synapses, both unpaired and walk-through groups significantly decreased mean mIPSC amplitudes, showing the experience-induced reduction of postsynaptic GABAA receptor-mediated currents. Unlike the plasticity at CA1 synapses, it was difficult to explain the learning- specific plasticity at the synapses. However, overall multivariate analysis using four variables of mE(I)PSC responses revealed experience-specific changes in the diversity, suggesting that the diversity of excitatory/inhibitory synapses onto granule cells differs among the past experience of animals include the learning. In comparison with CA1 pyramidal neurons, granule cells consistently showed greater amplitude and frequency of mE(I)PSCs. Fluctuation analysis further revealed that granule cells provide more postsynaptic AMPA receptor channels and greater single-channel current of GABAA receptors of than CA1 pyramidal neurons. These findings show functional differences between two types of principal cells in the hippocampus.
Creators : Han Thiri Zin Sakimoto Yuya Mitsushima Dai Publishers : Yamaguchi University School of Medicine
Incontinentia pigmenti (IP; OMIM# 308300) is a rare inherited disease caused by a mutation of IKBKG, which is also known as NEMO, located on Xq28. IP patients usually present with abnormalities of skin, eyes, nails and central nervous system. The neurological damege, which occur usually from neonatal through the early infantile period, leads to neulogical complication such as development retardation, motor paralysis and epilepsy. However, there has been little study done concerning the effect of therapy for the neural abnormalities. We have investigated the clinical findings in a female IP case with a novel mutation of IKBKG for six years due to disclosing the neurological prognosis and the immunological features. It is hoped that the present study will contribute to a better management of IP patients.
Creators : Sakata Yasufumi Hirano Reiji Yasudo Hiroki Shimomura Yutaka Takada Hidetoshi Suehiro Yutaka Ohga Shouichi Hasegawa Shunji Publishers : Yamaguchi University School of Medicine
Androgen receptor (AR)-signaling plays an important role in promoting tumor cell survival and the development of castration-resistant prostate cancer (CRPC). Androgen deprivation therapy is the basic therapeutic strategy for AR signaling blockade, but that effects wonʼt last long and most of metastatic prostate cancer show castration resistance. Recently, new agents, AR Axis Targeted agents (ARAT), have been developed. We have been developing our bench-to-bedside translational research to elucidate the mechanisms of drug resistance in prostate cancer. This review describes our investigational results and recent advances in CRPC with ARAT treatment strategy.
Creators : Matsumoto Hiroaki Matsuyama Hideyasu Publishers : Yamaguchi University School of Medicine
Journal of higher education Volume 18 pp. 10 - 22
published_at 2021-03
2021年度入試からの実施を目指した大学入試改革は, 改革の柱であった大学共通テストにおける記述式問題の導入, 大学入試英語成績提供システムの導入, 大学入試の選抜資料として高校調査書の積極的活用が見送られ, 大学は引き続き検討をしなければならない。18歳人口が減少する中, 大学は日本人の18歳入学者を主な対象として想定してきた従来のモデルから脱却する必要がある。山口大学における次なる入試改革の課題は何であるのか, 山口大学の入試の現状, 山口県の高校生の状況を再検討することが本稿の目的である。
Creators : Hayashi Hiroko Publishers : 山口大学教育・学生支援機構
Journal of higher education Volume 19 pp. 1 - 9
published_at 2022-03
現在, 通信制課程の高校および生徒は増加傾向にある。1990年代以降, 通信制課程においては, 既存の高校教育の教育システムや教育方針を変える新しい教育の模索が行われている。通信制課程の実態を把握することは, 入学者受け入れを見直す上において重要と考え, 全日制課程との比較から通信制課程の進路選択を把握した。結果, 通信制課程の生徒は, 他者との比較の中で生じる能力アイデンティティの揺らぎや自己意識が高校卒業後の進路希望に影響せず, 大人の勧め等の影響を受けながら「高等学校卒業」という目的に向けて自分が選択した学びを進めているようすが明らかになった。
Creators : Hayashi Hiroko Publishers : 山口大学教育・学生支援機構
Journal of higher education Volume 19 pp. 10 - 24
published_at 2022-03
本稿の目的は, 山口大学AO入試の実施20年という節目にあたりAO入試の改善を見直し, 今後の総合型選抜改善の課題を明らかにするとともに, 入学者追跡調査による入試の検証の在り方の課題を明らかにすることである。今後, 追跡調査の重要性が増す中, これまでの山口大学の入試効果検証を維持しつつ, 総合型選抜においては新たな志願者獲得に向けての抜本的な見直しが必要と考える。
Creators : Takemoto Marie Hayashi Hiroko Publishers : 山口大学教育・学生支援機構
東亞経濟研究 Volume 75 Issue 1-2 pp. 1 - 23
published_at 2017-01-31
Creators : Yamane Hirofumi Tsukada Hiroto Publishers : 山口大学東亜経済学会
山口経済学雑誌 Volume 66 Issue 6 pp. 985 - 1000
published_at 2018-03-31
Creators : Tsukada Hiroto Publishers : 山口大學經濟學會
Journal of KIBI International University. Health and natural sciences Volume 23 pp. 1 - 6
published_at 2013-03-31
Creators : Kawaura Akihiko Tanida Noritoshi Tamari Kotaro Morishita Motoyoshi Akiyama Junichi Matsuda Tomoko Ohmori Naoki Joko Miki Oku Keiko Shindo Hideki Abe Chihiro Yamaguchi Naoya Fukuda Shiho Publishers : 吉備国際大学
Creators : Yasuda Mayumi Kaino Seiji Tsuyama Takanori Fujimoto Yuko Amano Shogo Harima Hirofumi Suenaga Shigeyuki Sakaida Isao Publishers : Yamaguchi University School of Medicine
Journal of cross-cultural studies Volume 15 pp. 98 - 106
published_at 2021-03-31
Creators : Nie Ning Publishers : 山口大学人文学部異文化交流研究施設
東亞経濟研究 Volume 77 Issue 1-2 pp. 44 - 35
published_at 2019-01-31
Creators : Saito Tadashi Publishers : 山口大学東亜経済学会
Microscopic observation is one of the most basic and important skills for experiments in biology classes from compulsory education through to higher education. Microscopic observation in biology can help us better understand the microstructures of organisms and convey notions of beauty and fascination regarding the detailed nature of the microworld, which we cannot observe through our unaided eyes. However, many lab classes were postponed for the summer break because it was difficult for the faculty to conduct lab classes using equipment such as microscopes for non-face-toface learning at the university in the beginning of the COVID-19 pandemic. Under this situation, we planned that students do the experiment at home using handmade microscope. Students could make a simple Leeuwenhoek microscope very easily and use to understand the principle of the microscope. A non-face-to-face class required students to take the initiative in learning, which led to a better understanding of the principles of microscopy. Hence, the future integration of this nonface-to-face learning using a handmade microscope into an existing face-to-face lab class will be very useful for the teaching of science, especially biology, at many schools by science teachers and researchers.
Creators : Uemura Takumi 山中 明 Kitazawa Chisato Publishers : Faculty of Education, Yamaguchi University
Creators : Miyoshi Tetsuhiko Kaminishi Ken Kawano Syunichi Publishers : 山口大学工学部
山口経済学雑誌 Volume 67 Issue 5 pp. 311 - 339
published_at 2019-03-31
Creators : Yamashita Satoshi Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 369 - 385
published_at 2019-03-31
Creators : Watanabe Koichiro Matsuda Atsuro Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 427 - 436
published_at 2019-03-31
Creators : Umada Tetsuji Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 461 - 479
published_at 2019-03-31
Creators : Nakamura Mikiko Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 481 - 498
published_at 2019-03-31
Creators : Yanagisawa Noboru Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 499 - 517
published_at 2019-03-31
Creators : Sakuraba Osamu Ohba Shiro Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 5 pp. 519 - 547
published_at 2019-03-31
Creators : Sawa Kishiro Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 6 pp. 581 - 598
published_at 2019-03-31
Creators : Nakamura Mikiko Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 6 pp. 661 - 702
published_at 2019-03-31
Creators : Sakuraba Osamu Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 6 pp. 703 - 719
published_at 2019-03-31
Creators : Yanagisawa Noboru Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 6 pp. 721 - 754
published_at 2019-03-31
Creators : Kajiwara Kensuke Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 67 Issue 6 pp. 771 - 802
published_at 2019-03-31
Creators : Sawa Kishiro Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 1-2 pp. 39 - 54
published_at 2019-07-30
Creators : Risalat Ablim Asamizu Munehiko Publishers : 山口大學經濟學會
山口経済学雜誌 Volume 68 Issue 1-2 pp. 55 - 70
published_at 2019-07-31
Creators : Chen Liqian Publishers : 山口大学経済学会
山口経済学雑誌 Volume 68 Issue 3 pp. 81 - 98
published_at 2019-11-30
Creators : Akkemik K. Ali Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 3 pp. 99 - 118
published_at 2019-11-30
Creators : Umada Tetsuji Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 3 pp. 143 - 208
published_at 2019-11-30
Creators : Sawa Kishiro Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 4 pp. 221 - 234
published_at 2020-03-31
Creators : Umada Tetsuji Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 4 pp. 341 - 360
published_at 2020-03-31
Creators : Kawamura Kazuma Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 4 pp. 361 - 401
published_at 2020-03-31
Creators : Kajiwara Kensuke Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 5 pp. 449 - 464
published_at 2020-03-31
Creators : Asamizu Munehiko Kuo Shuchuan Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 5 pp. 465 - 477
published_at 2020-03-31
Creators : Umada Tetsuji Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 5 pp. 597 - 636
published_at 2020-03-31
Creators : Kajiwara Kensuke Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 6 pp. 859 - 880
published_at 2020-03-31
Creators : Yanagisawa Noboru Publishers : 山口大學經濟學會
山口経済学雑誌 Volume 68 Issue 6 pp. 713 - 733
published_at 2020-03-31
Creators : Umada Tetsuji Publishers : 山口大學經濟學會