山口医学

山口大学医学会

PISSN : 0513-1731
NCID : AN00243156

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山口医学 Volume 70 Issue 4
published_at 2021-12-02

Rapid proliferation of CD22 negative leukemic cells after inotuzumab ozogamicin therapy for relapsed acute lymphoblastic leukemia

Inotuzumab ozogamicinの投与後にCD22陰性白血病細胞が急増した再発急性リンパ性白血病
Sakai Kohei
Tominaga Takayuki
Matsumura Takuro
Tanaka Shinsuke
Takahashi Toru
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B030070000404.pdf
We report the case of a 48-year-old woman with relapsed B-lineage acute lymphoblastic leukemia(B-ALL)following cord blood transplantation, in which leukemic cell CD22 antigens became negative after a single administration of inotuzumab ozogamicin(InO).At relapse, a major part of leukemic cells expressed CD19 and CD22 antigens, however some leukemic cells were negative for CD22. As treatment with blinatumomab proved ineffective, InO therapy was subsequently initiated
Creator Keywords
急性リンパ性白血病
CD22
イノツズマブ・オゾガマイシン