Mini-transplant and imatinib mesylate were temporarily effective in a patient with ph1 positive acute lymphoblastic leukemia which had been refractory to conventional chemotherapy

Mini-transplant was performed in a patient with Philadelphia chromosome (Ph1) positive acute lymphoblastic leukemia (ALL) which had been refractory to repeated courses of chemotherapy. Decrease of leukemic cells and mixed chimerism were observed during a first month. However, leukemic cells increased thereafter, and donor leukocyte infusion(DLI) was ineffective. Subsequently, Imatinib Mesylate was administered and leukemic cells decreased for 2 months, however lekemic cells increased thereafter. These treatments were temporarily effective for Ph1 positive ALL which was refractory to conventional chemotherapy. The improvement of these treatment strategies and accumulation of these cases are necessary.

Ph1陽性ALL

ミニ移植

Imatinib Mesylate

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである