RANTES Inhibits Stress-induced Apoptosis

Chemokines induce cell migrarion and activation by binding to specific G protein coupled receptors on target cells. The chemokine RANTES (regulated on activation, normal T cell expressed and secreted) induces T cell activation and proliferation. In this study, using CCR5-expressed HEK293 cells, RANTES was demonstrated to inhibit stress (UV and etoposide) induced apoptosis through CCR5, a RANTES receptor. RANTES activated extracellular signal-regulated kinase (ERK) and Akt, which is downstream from phosphatidylinositol 3 kinase (PI3K). A MEKI inhibitor, PD98059, inhibited RANTES-mediated ERK activation and abrogated the anti-apoptotic effects of RANTES, while wortmannin, a PI3K inhibitor, did not These findings indicate that ERK activation is required for RANTES-mediated inhibition of stress- induced apoptosis.

RANTES

CCR5

アポトーシス