Gene Clustering and Environmental Factors Linked to Susceptibility to Psoriasis Vulgaris

Psoriasis vulgaris is a systemic and genetic disease including cellular immune responses and metabolic disorders of glucose,lipids,and calorie intake The purpose of the present review is to identify gene clustering including HLA class I genes and environmental modifiers necessary for the development of psoriasis. Regarding genetic analysis,the antigen frequency of HLA-Cw6(Cw*0602)was increased in psoriasis vulgaris.With respect to metabolism,hyperinsulinemia without diabetes mellitus and low serum level of linoleic acid were associated with the disease. Immunologically,streptococcal M protein,which shares epitopes with the skin and synovium,was probably involved as superantigen but not specific antigen. T cell and monocyte play a crucial role for the development of psoriasis vulgaris, based on the facts that psoriasis can be transferred by bone marrow transplantation and that CTLA-4 immunoglobulin diminished functions of monocytes obtained from psoriatics,leading to improvement of psoriasis eruption.The results including us indicate that HLA-linked as well as novel unlinked loci(17q.4q,16q,and 20p) contribute significantly to psoriasis susceptibility.

乾癬

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