Comparison of Culture Studies, Rapid Urease Tests, Histological Studies and Helicobacter pylori-specific lgG Antibody for Detection Of Helicobacter pylori.

(Background) Helicobacter pylori (H. pylori) is now accepted as an etiological agent of gastritis. Its strong association with peptic ulcer and gastric cancer is also recognized. A number of tests have currently been used to detect H. pylori in biopsy specimens from gastrointestinal tract. But no tests exist which give satisfactory results in both high sensitivity and high specificity. Consequently, the presence of H. pylori has been diagnosed by a combination of tests. The purpose of this study is to assess the sensitibity of popular methods to detect H. pylori and create possible clinical application. (Methods) I : Ninety consecutive endoscopic antral and corpus biopsy specimens obtained from patients at the Yamaguchi university hospital were analyzed by culture studies, rapid urease tests (RUT), and histological staining (H.E. staining) to detect H. pylori. 2: In 35 patients, we compared the titer of H. pylori-specific lgG antibody with the results of culture. (Results and Conculusion) 1 : The test with the highest positive rate was RUT. As RUT turned to be false negative after eradication therapy in some cases, we reccomended to perform culture studies together with RUT. 2: The diagnostic value of the detection of H. pylori specific lgG antibody was compatible with the results from culture study. Although, appropriate cut-off values should be set after accumutating data on the same line with this study.

Helicobacter pylori

培養液

RUT

鏡検法

抗H.pylori Ig-G抗体法の比較