Evaluation of the Liver Function for Patients with Chronic Liver Diseases Using ^<99m>Tc-Galactosyl Human Serum Albuminw [^<99m>Tc-GSA] Liver Scintigraphy

^<99m>Tc-galactosyl human serum albumin [^<99m>Tc-GSA] is a new scintigraphic agent which binds specifically to asialoglycaprotein-receptor on the hepatic cell membrane. The new liver scintigraphy using ^<99m>Tc-GSA was pew formed in 30 patients with chronic liver diseases to evaluate the residual liver function. Two parameters were obtained from ^<99m>Tc-GSA time activity cuves of both the heart and the liver. One was [HH15] (Clearance Index), which was the ratio of radioactivity of the liver at 15 min over that at 3 min after injection. The other wasw [LHL15] (Receptor Index), the ratio of radio-activity of the liver over that of the liver plus heart at 15 min. Significant decrease in LHL15 and increase in HH15 value were observed in accordance with severities of the liver damage and clinical aggravation. These parameters correlated significantly with Child-Pugh score, glucagon test, ICG-R_<15>, serum albumin levels, cholinesterase, prothrombin time and hepaplastin test also. In conclusion, these findings indicate that ^<99m>Tc-GSA liver scintigraphy is useful method evaluating the liver function for patients with chronic liver disease.

アシアロ糖タンパクレセプター

<99m>^Tc-Galactosyl Human Serum Albumin

<99m>^Tc-GSA

肝予備能

肝シンチグラフィ