山口医学
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山口医学 Volume 41 Issue 1
published_at 1992-02
Early Phase II Study of Hypoxic Cell Radiosensitizer RK28 in Yamaguchi University School of Medicine and Shimonoseki General Municipal Hospital
放射線増感剤RK28前期第II相試験結果 : 山口大学医学部付属病院および下関市立中央病院における集計
Ebe kazuyu
Nagaoka Sakae
Arita takeshi
Suda hiroki
Honma Yutaka
Chozi Takashi
Soezima Kyoko
Kawamura Mitsutoshi
Okada Morihisa
Karino Yuichi
Nakada Taishi
Nakanishi Takashi
About This Article
Descriptions
Fifteen patients with malignant tumors were entered into an early phase II study of hypoxic cell radiosensitive RK28 during Nov. 1989 to Mar. 1991. The treatment regimen consisted of a 0.4g/m^2 IV, I A infusion twice a week or LI(local injection). Fourteen patients were evaluable for response. Six partial responses were observed. The main adverse effect was nausea/vomiting (53%). The results of animal experiments in RK28 I A infusion on rabbit VX2 tumor system were also demonstrated.
Creator Keywords
放射線増感剤
RK28
前期第II相試験
静注
動注
局注
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