An evaluation of clinicopathplogical findings for molorectal cancer with liver metastasis and local recurrence

We studied colorectal cancers with early liver metastasis and local recurrence clinicopathologically and investigated factors relating to their prognoses. There were no significant difference between a recurrence group (R group) and a non-recurrence group (NR group) with regard to histological type, n-factor, ly-factor and preoperative CA19-9 level. Invasions of tumors through the bowel wall were pm in 1 case and ss・s・a_1・a_2 in 9 cases for NR group, and pm in 1, ss・s・a_1・a_2 in 3, and si. Ai in 3 for R group, with a significant difference (p＝0.05). V-factors were vo in 3 cases and v_1 in 4 for R group, and vo in 9 and v_1 in 1 for NR group with a significant difference (p＝0.06). Preoperative CEA levels were positive in 4 and negative in 3 for R group, and positive in 1 and negative in 9 for NR group, with a significant difference (p＜0.05). With regard to postoperative CEA and CA 19-9 levels, significant differences were noticed between R and NR groups (p＜0.01). We enphasize that postoperative chemotherapy should be associated with surgical resection of colorectal cancer which reveals deep invasion through the bowel wall, positive v-factor, and positive preoperative CEA level, in order to prevent from recurring. In addition we must not neglect efforts to find the recurrence in an early stage by means of measurments of postoperative CEA and CA 19-9 levels, and imagings.