Clinical studies on the diagnosis and the prevention of non-A, non-B posttransfusion hepatitis

Clinical studies were made from view points of the diagnosis and the prevention of non-A, non-B posttransfusion hepatitis (PTH) . Important factors of the diagnostic criterion for PTH were thought to be incubation time and value of liver dysfunction. From the analysis of 58cases of PTH and 96 cases transfused, it was suggested that the proper diagnostic criterion for PTH was ”more than 100 u-elevation of GPT in the period of 2 weeks to 4 months after blood transfusion”. The prospective study on the relationship between guanase activity of blood for transfusion and the occurrence of PTH suggests that the occurrence of PTH is depend on volume of transfused blood and guanase activity in it. Among these factors, guanase activity in blood for transfusion seemed to be more important factor in association with PTH. In conclusion, it is useful for the prevention of PTH to measure guanase activity in blood for transfusion.