Changes in the Activity of the Rat Brain Concerned with the Rising Phase of Fever

The metabolic activity of the brain regions of rats during the rising phase of fever was studied with the [^<14>C] deoxyglucose ([^<14>C] DG) technique. The autoradiogram, which was obtained 45 min after the injections of the pyrogenic substance and [^<14>C] DG, was examined visually and analyzed by ratio of [^<14>C] incorporation into selected brain regions to that of the corpus callosum. Fever was induced as follows (1) single injection of endogenous pyrogen (EP) into the preoptic/anterior hypothalamic region (POAH)