XY and XX Complete Moles: Clinical and Morphologic Correlations

The results of clinical, morphological and histological analysis of 9XY complete moles (6 karyo-typed, 3 Y-chromatin positive) were compared with those of 16 XX moles. Of the 9 XY moles, 5 were proven to result from dispermy while all the 16 XX moles studied originated from the doubling of a haploid sperm. Delayed decrease or rebound of urinary (or serum) hCG levels was noted in the mothers of 3 out of 9 XY moles and in those of 5 out of 15 XX moles followed-up. The mother of an XY mole was treated for lung metastatis but it remained stable over a 4 years' follow-up period. No appreciable difference was noted in the gross and microscopic findings between the XY and the XX moles. On the other hand, differences were noted between younger (12 weeks or less of menstrual age) and older (13 weeks or more) moles.