The bulletin of the Yamaguchi Medical School
Continued by：Medical Science & Innovation
EISSN：2758-5441
Back to Top
Permalink : https://petit.lib.yamaguchi-u.ac.jp/27361
The bulletin of the Yamaguchi Medical School Volume 64 Issue 3-4
published_at 2017
An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
About This Article
Descriptions
ESR1 expression was tissue-specific, being high in the endometrium and mammary gland and low/nil in the placenta and skin.A long-standing question was how this tissue-specific expression of ESR1 was regulated. In other genes, DNA methylation of a region called the T-DMR (tissue-dependent and differentially methylated region) has been associated with tissue-specific gene expression.We recently found that human ESR1 has a T-DMR and DNA methylation of the T-DMR, but not the promoter region, regulates its tissue-specific expression. Furthermore, we revealed that EGR1 is a possible transcription factor to bind the T-DMR and upregulate ESR1 expression under DNA hypomethylation of the T-DMR.
Creator Keywords
estrogen receptor 1 (ESR1)
tissue-specific expression
DNA methylation
tissue-dependent and differentially methylated region
breast cancer
Other Article