The bulletin of the Yamaguchi Medical School

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EISSN：2758-5441

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The bulletin of the Yamaguchi Medical School Volume 50 Issue 1-4
published_at 2003-12

Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma

Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma
Ohi Ritsuko
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A020050000108.pdf
About This Article
Descriptions
Osteosarcoma (OS) and malignant fibrous histiocytoma (MFH) are the most frequent sarcomas of the bones and soft tissues, respectivery. These tumors share a spectrum of histpathologic features. In order to elucidate the similarity and difference of tumor-specific genetic alterations between them, we analyzed DNA copy number aberrations of 7 Oss and 12 MFHs using comparative genomic hybridization (CGH). In OS a DNA copy number gain of chromosome 1p21-pter was the most frequent aberration (85.7%
Creator Keywords
comparetive genomic hybridization
DNA copy number aberrations
osteosarcoma
malignant fibrous histiocytoma
differential diagnosis
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