Troglitazone-Induced Liver Injury Diagnosed by a Laparoscopic Examination in Its Asymptomatic Stage

A 56-year-old diabetic woman had been taking glibenclamide (10 mg daily) plus voglibose (0.6 mg daily) for recent 4 years without a successful response. Three months after troglitazone (400 mg daily) was started in addition to glibenclamide, liver dysfunction was found by chance. She demonstrated no symptoms, histological examination, however, revealed a substantial hepatocelluar necrosis mainly in the peri-central vein areas, which was consistent with an idiosyncratic drug reaction. Since troglitazoneinduced liver dtsfunction was strongly suggested, administaration of troglitazone was terminated and abnormal values of liver-chemistry returned to normal in two months.

troglitazone

diabetes mellitus

liver injury