The bulletin of the Yamaguchi Medical School

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EISSN:2758-5441

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The bulletin of the Yamaguchi Medical School Volume 45 Issue 1-4
published_at 1998-12

Detection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma

Detection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma
Morita Nobuyoshi
Inokuchi Tomohiro
Tsushimi Takahiro
Hayashi Daisuke
Okamura Keiji
Shinagawa Hidetaka
Orita Masahiko
Noshima Shinji
Esato Kensuke
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A020045000108.pdf
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Background and Aim : It is well known that pancreatic adenocarcinomas harber K-ras gene point mutations, which are frequently restricted to codon 12. Thus, the detection of K-ras codon 12 mutations in pancreatic or duodenal juice may did in the diagnosis of pancreatic adenocarcinomas. In the present study, we investigated whether or not portal blood collected during surgery for pancreatic adenocarcinoma contains the K-ras codon 12 mutation. Methods : During radical resection for pancreatic adenocarcinoma, 10ml of portal blood was taken twice
Creator Keywords
K-ras codon 12 mutation
liver metastasis
pancreas carcinoma
portal blood