The bulletin of the Yamaguchi Medical School

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The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4
published_at 1996-12

A Case of Erythrocyte membrane Protein 4.2 Deficiency with Coombs Negative Hemolytic Anemia

A Case of Erythrocyte membrane Protein 4.2 Deficiency with Coombs Negative Hemolytic Anemia
Nishimura Manabu
Azuno Yoichi
Kora Yukari
Matsutani Akira
Fujita Naoki
Shino Kazuko
Kaku Kohei
Matsumoto Noboru
Kaneko Toshio
Oka Yoshitomo
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About This Article
Descriptions
A patient with mild hemolytic anemia and osmotically fragile, stomatocytic erythrocytes was studied. Analysis of the erythrocyte membrane proteins by SDS-PAGE revealed a partial deficiency of protein 4.2. All the other membrance proteins in the erythrocytes were normal. Enzyme activities in the erythrocytes were normal or increased. Deficieny of protein 4.2 is likely to be associated eith the hemolytic anemia and stomatocytosis in this patient.
Creator Keywords
Hemolytic anemia
Erythrocyte
Protein 4.2
Stomatocytosis
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