Influence of Atherosclerotic Change in the Coronary Arteries of Rat Heart snd Heart-ling Transplants on Plasma Lipid, Blood Glucose Levels and Platelet Aggregation

We examined the change in plasma lipid levels, blood glucose levels and platelet aggregation two months after transplantation in both rat heart and heart-lung transplant models. Atherosclerosis had occurred in grafted heart in both groups by two months after the transplantation. Wehave previously shown that atherosclerotic changes in the grafted heart were more advanced in the heart transplantation group than the heart-lung transplantation group. Two months after the transplantation there was no significant difference in plasma lipid levels, blood glucose levels and platelet aggregation between the transplanted groups and a control group. It was concluded that plasma lipid, blood glucose levels and platelet aggregation are not related to the atherosclerotic change in the grafted heart.

Heart transplantation

Heart-lung transplantation

Plasma lipid levels

Platelet aggregation

Chronic rejection