The bulletin of the Yamaguchi Medical School

Continued by：Medical Science & Innovation
EISSN：2758-5441

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The bulletin of the Yamaguchi Medical School Volume 36 Issue 1-2

published_at 1989-06

Effect of Intravasclar Influsion of Endogenous Pyrogen or Prostaglandin E2 on Neuronal Activity of Rat's Hypothalamus

Sakata Yoshiyuki

Watanabe Tatsuo

Morimoto Akio

Murakami Naotoshi

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About This Article

Descriptions

We investigated the effects of intracarotid infusion of prostaglandin E2 or intravenous infusion of an endogenous pyrogen on the neuronal activity of the neuronal activity of the preoptic and anterior hypothalamic (PO/AH) region in rats. The present results suggest that thermore sponsive neurons of the PO/AH region respond well to intravascular application of prostaglandin E2 or the endogenous pyrogen, compared with thermally insensive neurons. Intravenous infusion of the endogenous pyrogen attenuated the activities of warm-responsive and facilitated those of cold-responsive neurons. However, the direction of neuronal response induced by intracarotid infusion of prostaglandin E2 could not be categorized based on the thermoresposiveness of the individual neuron.

Creator Keywords

Fever

Thermoregulation

Prostaglandin

Endogenous pyrogen

Themoresponsive neuron

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