The bulletin of the Yamaguchi Medical School

Continued by:Medical Science & Innovation
EISSN:2758-5441

Back to Top

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1
published_at 1985-12

Ultrastructural Study on the Spleens of 28 Patients with ITP:Platelet Phagocytosis of Cordal Macrophages

Ultrastructural Study on the Spleens of 28 Patients with ITP:Platelet Phagocytosis of Cordal Macrophages
Ishihara Tokuhiro
Yamashita Yoshimi
Yokota Tadaaki
Kamei Toshiaki
Uchino Fumiya
Matsumoto Noboru
fulltext
3.94 MB
A020032000101.pdf
Descriptions
Spleens of 28 patients with idiopatic thrombocytopenic purpura have been observed histologically, immunohistologically and electron microscopically. Spleens of fifteen patients had the foamy cells in the red pulp. Some foamy cells had positive materials for anti-human platelet antibody, using the unlabelled immunoperoxidase method. Electorn microscopically, many platelets in varying stages of intracellular digestion from intact-appearing platelets to myelinlike materials were disclosed in the foamy cells. We suggest that there are two types of the macrophage in the spleen from patients with ITP. One does not reveal foamy cytoplasm, because phagocytized are immediately digested by the lysosomal enzyme within cytoplasm of macrophages. The other has foamy cytoplasm, because phagocytized platelets are incompletely digested and remain as myelinlike materials within cytoplasm of macrophages.
Creator Keywords
ITP
Ultrastructure
Spleen
Platelet
Cordal macrophage