The bulletin of the Yamaguchi Medical School

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EISSN:2758-5441

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The bulletin of the Yamaguchi Medical School Volume 30 Issue 1
published_at 1983-12

Prolymphocytic Leukemia : Report of a Case with Autopsy Findings

Prolymphocytic Leukemia : Report of a Case with Autopsy Findings
Okubo Masaki
Hiroshige Yukio
Kaku Kohei
Kamei Toshiaki
Ishiguro Norio
Matsumoto Noboru
Kaneko Toshio
fulltext
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A020030000106.pdf
Descriptions
A case of prolymhocytic leukemia, a rare variant of chronic lymphocytic leukemia, was reported with autopsy findings. The patient was a 65-year-old woman who was chinically characterized by huge splenomegaly, mid lymphadenopathy and red skin eruption due to leukemic cell infiltration. The leukemic cellls in the peripheral blood and in the bone marrow had pale bluish cytoplasm and one large prominent nucleolus. Transmission electron microscopy also revealed a chromatin structure intermediate between that of a mature lymphocyte and that of a lymphoblast. Surfase maker studies suggested T-cell origin. Irradia tion to the spleen and chemotherapy with cyclophosphamide. And vincristine failed to induce remission.
Creator Keywords
Prolymphocytic Leukemia
T-cell
Combination Chemotherapy