Treatment of Hepatocellular Carcinoma by Inter-arterial Infusion with Mitomycin C

The effect of disopyramide on maximum upstroke velocity (V_max) of cardiac action potential was studied with particular reference to its time- and voltage-dependence. The time-dependence (recovery process of V_max during diastolic interval) was assessed by introducing premature stimuli or by interrupting stimuli. The voltage-dependence was examined by changing the external K^+ concentration (〔K^+〕_0). In the presence of the drug, the recovery process of V_max slowed at high 〔K^+〕_0 in early stages and at low 〔K^+〕_0 in late stages during the diastolic interval. Relevance of the present findings to clinical utility of disopyramide as an antiarrhythmic agent was discussed.

liver carcinoma

chemotherapy

Mitomycin C