Syndrome Neuro-Vegetatif Malin

Three cases of presumed syndrome malin caused by neuroleptic medication were presented. These patients were all juvenile, aged around 20 years, with one of them having mental subnormality. These findings strongly suggest fragility somewhere in the central nervous system. It seems also quite likely that a debility resulting from refusal to take food, insomnia and psychomotor excitement and unfavorable climatic conditions (e.g. high temperature and high humidity) might play a major role in the causation of syndrome malin. Our present cases point to the possibility that the use of haloperidol, levomepromazine, chlorpromazine, fluphenazine enanthate or a combination of chlorpromazine and prmethazine, among other neuroleptic drugs currently available, might be implicated as a causative agent. In this connection, it is interesting to note that medication with chlorpromazine brought about a symptomatic remission in one of our cases.