The Effect of the Carcinogenesis and the presence of Neoplastic Cells on the Mitotic Activity of Oral Epithelia in Rats and Mice

Using the rats fed DAB diet and the mice transplanted with Ehrlich ascites tumor, the relation between mitotic activity of the epithelium of the oral cavity and the presence of neoplastic cells was observed with colchicine technique. The epithelium of the oral cavity and the presence of neoplastic cells was observed with colchicine technique. The effect of anabolic steroid hormone was also examined. In the male rats received the ASH, the incidence of hepatoma was strictly lower than that of contral rats 150 days after administration of DAB. Mitotic rate of epithelial cells of buccal mucosa from hepatoma-bearing rats was inhibited more than that from non-hepatoma-bearing rats, and each of them was divided by a borderline of 2.0 per cent level. The tongue surface of mice transplanted with Ehrlich ascites tumor showed clearly higher mitotic activity in the group treated with ASH than in the nontreated group. Conversely, mitotic rate of Ehrlich ascites tumor cells was inhibited in the mice treated with ASH. From these results, it was discussed on mitosis stimulating agent in the process of carcinogenesis.