The bulletin of the Yamaguchi Medical School

Continued by:Medical Science & Innovation
EISSN:2758-5441

Back to Top

The bulletin of the Yamaguchi Medical School Volume 15 Issue 1
published_at 1968-03

Effect of Various Antitumor Agents on Electrokinetic Behaviour of Ehrlich’ Ascites Tumor Cells and Mouse Erythrocytes

Effect of Various Antitumor Agents on Electrokinetic Behaviour of Ehrlich’ Ascites Tumor Cells and Mouse Erythrocytes
Ito Hirotada
fulltext
715 KB
A020015000104.pdf
Descriptions
1. The effects of various antitumor agents on the electrophoretic mobility of Ehrlich' ascites tumor cells and mouse erythrocytes were examined in vitro and in vivo. 2. These antitumor agents had no estimable effect on the electrophoretic behaviour of mouse erythrocyte membrane, while significant decrease was obtained in the electrophoretic mobility of Ehrlich' ascites tumor cells treated with Toyomycin and Mitomycin. 3. The isoelectric point of Ehrlich' ascites tumor cell was supposed to be about pH 4.l. These values indicate that the surfaces of the ascites tumor cells are amphoric and are strongly electronegative at neutral pH. The significant decrease on the electrophoretic mobility of the ascites tumor cells treated with Mitomycin and Tomyocin was obtained mainly on the alkali side of pH. 4. The electrophoretic mobility of the ascites tumor cells was influenced by the ionic strength at pH 7.3. The value decreased according to increase of ionic strength."