The Effect of Altered Reticuloendothelial Function on Electroshock Seizure Pattern

The effect of altered RE function on electroshock seizure pattern was studied in mice. RES depressants (Perikan ink and methyl palmitate) produced the prolongation of TF and shortening of TE (decrease in brain excitability), while RES stimulants (zymosan and diethylstilbesterol) produced the prolongation of TE and shortening of TF (increased brain excitability). The effect of the RES stimulants on TE was more pronaunced in adrenalectomized mice and was largely abolished in RES blocked mice. This indicates that the prolongation of TE produced by the RES stimulants was not mediated by the adrenal gland and was at least mostly caused by increased RE function. From these observations, it is reasonable to conclude that altered RE function produces changes in electroshock seizure pattern.