- Saeki Issei
Affiliate Master Yamaguchi University
Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Body composition as a novel prognostic biomarker for the patients with advanced hepatocellular carcinoma
山口医学 Volume 70 Issue 4 pp. 157 - 164
Creators : Saeki Issei Publishers : 山口大学医学会
Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?
山口医学 Volume 70 Issue 3 pp. 89 - 98
We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.
Creators : Yamasaki Ayano Suehiro Yutaka Hoshida Tomomi Saeki Issei Yamauchi Kotoh Yurika Matsumoto Toshihiko Takami Taro Sakaida Isao Yamasaki Takahiro Publishers : 山口大学医学会
Utility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 29 - 35
Creators : Hanazono Tadasuke Hidaka Isao Maeda Masaki Saeki Issei Iwamoto Takuya Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 7 - 13
Creators : Fukui Yumi Saeki Issei Matsuda Takashi Maeda Masaki Hisanaga Takuro Iwamoto Takuya Matsumoto Toshihiko Hidaka Isao Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine
山口医学 Volume 66 Issue 3 pp. 163 - 168
Creators : Hisanaga Takuro Yamasaki Takahiro Maeda Masaki Iwamoto Takuya Saeki Issei Matsumoto Toshihiko Hidaka Isao Marumoto Yoshio Ishikawa Tsuyoshi Takami Taro Sakaida Isao Publishers : 山口大学医学会
A case of chronic hepatitis c with charcot-marie-tooth disease successfully treated with interferon beta and rivabirin combination therapy
山口医学 Volume 64 Issue 1 pp. 53 - 57
A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.
Creators : Matsuura Keiji Hidaka Isao Hanazono Tadasuke Saeki Issei Iwamoto Takuya Ishikawa Tsuyoshi Takami Taro Kawai Motoharu Terai Shuji Takashi Takashi Sakaida Isao Publishers : 山口大学医学会
A case of ruptured hepatocellular carcinoma immediately after transcatheter arterial chemoembolization
山口医学 Volume 64 Issue 1 pp. 35 - 40
Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.
Creators : Fukui Yumi Saeki Issei Hanazono Tadasuke Tanabe Norikazu Urata Yohei Hidaka Isao Terai Shuji Sakaida Isao Publishers : 山口大学医学会
Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells
Tissue engineering. Part B, Reviews Volume 20 Issue 3 pp. 206 - 210
Creators : Terai Shuji Takami Taro Yamamoto Naoki Fujisawa Koichi Ishikawa Tsuyoshi Urata Yohei Tanimoto Haruko Iwamoto Takuya Mizunaga Yuko Matsuda Takashi Oono Takashi Marumoto Miho Burganova Guzel R. Quintanilha Luiz Fernando Hidaka Isao Marumoto Yoshio Saeki Issei Uchida Koichi Yamasaki Takahiro Tani Kenji Taura Yasuho Fujii Yasuhiko Nishina Hiroshi Okita Kiwamu Sakaida Isao Publishers : Mary Ann Liebert
山口医学 Volume 63 Issue 1 pp. 53 - 60
Creators : Kawasato Ryo Shiratsuki Shogo Iwamoto Takuya Saeki Issei Urata Yohei Hidaka Isao Ishikawa Tsuyoshi Takami Taro Uchida Kouichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会
Hepatic arterial infusion chemotherapy in combination with pegylated interferon-α-2b for advanced hepatocellular carcinoma
Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 114 pp. 533 - 537
Creators : Okita Kohsuke Yamasaki Takahiro Hamabe Satoe Saeki Issei Harima Yohei Terai Shuji Sakaida Isao Publishers : Georg Thieme