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Hayasaki Mineo

Affiliate Master Yamaguchi University

Influence of immunosuppressants against Dirofilaria immitis infection in dogs

Japanese journal of veterinary science Volume 51 Issue 5 Page 955-960
published_at 1989
2008010281.pdf
[fulltext] 499 KB
Title
Influence of immunosuppressants against Dirofilaria immitis infection in dogs
Creators Hayasaki Mineo
Creators Ohishi Isamu
Creator Keywords
azathiopurine Dirofilaria immitis dog immunosuppressant prednisolone
Two immunosuppressive drugs, azathiopurine (AZP) and prednisolone (PDS), were examined on dogs experimentally infected with Dirofilaria immitis in order to estimate the involvement of immunological assail in rejecting the parasite by the host. AZP was orally administered to 3 dogs daily at a dosage of 1-10 mg/kg for a period from 3 days before infection until the end of the experiment. The dose was then varied and transiently ceased according to the severity of the side effects. PDS was subcutaneously administered daily to 2 dogs. They were administered 10 mg/kg of PDS from 3 days before infection to day 15 and 5.0-8.5 mg/kg from day 60 after infection to day 70. The serum D. immitis-specific antibody level assessed by an indirect hemagglutination test was steadily decreased in the AZP-medicated dogs. However, in the PDS-medicated dogs, the antibody titer was decreased until day 32 and, thereafter, was recovered. When all dogs were sacrificed between days 145-148, an average recovery rate of worms in both the AZP- and PDS-medicated dogs was 52.5% and 49.6%, respectively, while the controls showed 42.5%. The statistical analysis revealed no significant difference among the groups, indicationg that the administration of AZP and PDS was not effective in protecting the larvae from the host's immune attack.
Languages eng
Resource Type journal article
Publishers 日本獣医学会
Date Issued 1989
File Version Version of Record
Access Rights open access
Relations
[ISSN]0021-5295
[NCID]AA10521639
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja
[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511
Schools 農学部